This month, Aditi has joined Bert Poolman’s group group as part of the DC06 project. Her research will focus on the design and construction of membraneless protein compartments that can organize multiple enzymes and improve the efficiency of metabolic pathways.
She will employ intrinsically disordered protein domains and engineered tags such as PopTag to generate and optimize condensates. By systematically varying linker length and protein sequences, Aditi aims to create tunable systems in which condensate formation can be controlled by environmental cues including pH, light, or ligands. The long-term goal is to exploit these condensates to enhance enzyme kinetics, couple them to transport systems, and explore their role in the engineering of metabolic reaction networks.
Aditi completed her B.Sc. at the University of Hyderabad and her Master’s degree at the Weizmann Institute of Science in Israel. At Weizmann, she investigated protein folding within the GroEL/ES chaperonin system, using kinetic and thermodynamic approaches to elucidate folding pathways within the confined chaperonin cavity.
We look forward to Aditi’s contributions to advancing our understanding of protein-based condensates and their applications in expanding the fundamental science and development of synthetic biology.
Welcome to our Doctoral Network, Aditi!